Week 12 NFL picks, odds, 2022 best bets from advanced model: This five-way football parlay would pay out 25-1

Teams on opposite ends of the AFC standings will meet when the Houston Texans visit the Miami Dolphins on Sunday. The Dolphins began Week 12 tied atop the AFC East standings with the Buffalo Bills at 7-3, while the Texans are buried at the bottom of the AFC South at 1-8-1. Miami has won its last four games, most recently a 39-17 trouncing of the Browns. Quarterback Tua Tagovailoa has played himself into MVP contention. The Texans, meanwhile, are languishing. Rookie running back Dameon Pierce is a contender for Offensive Rookie of the Year, but he is all but the lone bright spot in what’s been a lost season for Houston. The Dolphins are 12.5-point favorites in the latest Week 12 NFL odds at Caesars Sportsbook. Which Week 12 NFL lines should you target with your Week 12 NFL bets? Before you make any Week 12 NFL picks or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine’s proven computer model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 12 of the 2022 NFL season on an incredible 155-109 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, the model has locked in five confident NFL best bets for Week 12. If you successfully parlay its picks, you’d be looking at a massive payout of around 25-1. You can only see the model’s Week 12 NFL picks at SportsLine.

Top Week 12 NFL picks

After simulating every game 10,000 times, the model is high on the Seattle Seahawks (-3.5) to cover against the Las Vegas Raiders. Both teams feature similarly inept defenses, but Seattle’s superior offense should carry the day at home.

The two defenses here have produced remarkably similar results. Seattle has allowed an average of 370 yards per game, while Las Vegas has conceded 370.5. The key difference is that Seattle’s offense has been one of the most surprising units in the NFL, while the Raiders have struggled at times to put points on the board. Josh McDaniels did get the better of a stout Denver defense last week, but that was after he was beaten by a Colts team led by Jeff Saturday, who had just been hired.

Given that the Seahawks will be playing at home with the raucous 12th Man backing them, it’s understandable why the model likes them. That is one reason the Seahawks are covering the spread in over 50% of simulations. See which other NFL parlay picks to make here.

How to make Week 12 NFL parlays

The model also jumped on four other NFL matchups where it says the line is way off, including backing an underdog that is projected to win outright. You can only see the model’s NFL Week 12 best bets and parlay at SportsLine.

What are the model’s top Week 12 NFL picks? And which other NFL matchups should you target for a strong 25-1 payout? Visit SportsLine now to see the Week 12 NFL best bets from a model on a 155-109 run on its top-rated picks, and find out.

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